What is Manganese Gluconate (Manganese Gluconate · Food Supplement & Feeding)?
Manganese gluconate is the preferred organic (gluconate) form of the trace element manganese in nutritional supplements. Manganese is a cofactor for enzymes necessary for energy metabolism, bone formation, connective tissue, and antioxidant defense (Mn-SOD). The gluconate form is common in low-dose multivitamin-mineral products.
- Molecular formula: C₁₂H₂₂MnO₁₄
- CAS number: 6485-39-8
- Form: Powder / Organic Manganese Salt
- Quality: Food / Pharmaceutical Grade
- Manganese(II) gluconate (C12H22MnO14) contains ~12.3% elemental manganese (100 mg ~12.3 mg Mn). Due to its organic form, it is considered to have good gastric tolerance and solubility.
What is Manganese Gluconate · Food Supplement & Feeding Used For? Why is it Used?
Manganese gluconate is suitable for multivitamin-mineral and bone health formulations seeking to provide dietary manganese at low doses with a well-soluble and taste-neutral organic form. It can be positioned with EFSA-approved functions for energy metabolism, bone, connective tissue, and protection against oxidative stress; due to the narrow safety margin, low-dose discipline is important.
Main areas of use: Dietary Supplements, Mineral Supplements, Beverage Powder Formulations, Carrot Flavored Products, Baby Foods, Animal Feeds, Cosmetics (Skincare).
Usage in Dietary Supplements
- Manganese source in multivitamin-mineral premixes: Typically used to provide manganese at the NRV (2 mg) level in multivitamin-mineral tablets and premixes; preferred due to its neutral taste and good solubility.
- Bone and joint health formulations: Serves as a manganese source in products supporting bone/connective tissue along with components such as calcium, vitamin D, zinc, and copper.
- Liquid and chewable forms: Due to its good solubility, it can be used as a manganese source in syrups, liquids, and chewable supplements.
- Low-dose discipline: Manganese has a narrow safety margin; supplements are typically formulated with low doses around 1–2 mg (excessive intake can be neurotoxic).
Usage in the Food Industry
- Nutrient source (fortification): It is among the authorized manganese sources for addition to food supplements and fortified foods in the EU.
- Feed trace element premixes: Manganese salts are also used as trace element sources in animal feed premixes; EFSA FEEDAP sets maximum Mn levels per species.
Effects on Health
Manganese is a mineral that plays a role in many fundamental functions in the body. The main functions authorized/evaluated by the European Food Safety Authority (EFSA):
- Energy metabolism: Manganese contributes to normal energy-yielding metabolism (EFSA).
- Protection of bones: Manganese contributes to the maintenance of normal bones (EFSA).
- Formation of connective tissue: Manganese contributes to the formation of normal connective tissue (EFSA).
- Protection from oxidative stress: Manganese contributes to the protection of cells from oxidative stress (Mn-SOD; EFSA).
Usage Limits in Dietary Supplements
- Nutrient Reference Value (NRV): Manganese NRV is 2 mg (1169/2011).
- Upper Intake Level (EFSA): EFSA has not established a classical numerical UL; in its 2023 opinion, it defined 8 mg/day as a 'safe intake level' for adults (2–7 mg/day for other groups).
- Turkish legislation (TETGK): Manganese is among the permitted minerals under the Turkish Dietary Supplements Regulation; the NRV % must be declared on the label. The current guideline should be followed for the permitted maximum amount (not fabricated).
Excess manganese can be neurotoxic (manganism); total intake should be kept within safe levels.
Technical Specifications
| Parameter | Value |
|---|---|
| Purity | 98.0% -102.0% |
| Appearance | White or light pink powder |
| Moisture | ≤5.0 % |
| Solubility | Soluble in Water |
Scientific Studies
The following independent researches relate to the bioavailability, usage, and effects of this mineral (levels of evidence are specified):
- PubMed 10475586 — Manganese deficiency and toxicity: a review examining the question of whether dietary manganese amounts are a cause for concern.
- PubMed 29849912 — A review investigating the connections between the essential element manganese, oxidative stress, and metabolic diseases.
- PubMed 28417441 — A review examining the relationships between essential manganese biology and manganese toxicity in neurological disease.
Technical Documents and Supply — Asuka Kimya
You can contact Asuka Kimya for SDS, TDS, CoA and supply conditions for Manganese Gluconate.
References
- efsa.onlinelibrary.wiley.com
- ods.od.nih.gov
- ncbi.nlm.nih.gov
- eur-lex.europa.eu
- pubmed.ncbi.nlm.nih.gov
- pubmed.ncbi.nlm.nih.gov
- pubmed.ncbi.nlm.nih.gov
The usage and health information on this page has been compiled from official legislation/institution sources (EFSA, NIH ODS, Turkish Food Codex, EUR-Lex) and independent scientific publications (PubMed). The product is a food supplement/food raw material; it does not aim to diagnose or treat diseases.